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Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus - PubMed
These SARS-CoV vaccines all induced antibody and protection against infection with SARS-CoV. However, challenge of mice given any of the vaccines led to occurrence of Th2-type immunopathology suggesting hypersensitivity to SARS-CoV components was induced. Caution in proceeding to application of...
pubmed.ncbi.nlm.nih.gov
Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus
Evaluations of an inactivated whole virus vaccine in ferrets and nonhuman primates and a virus-like-particle vaccine in mice induced protection against infection but challenged animals exhibited an immunopathologic-type lung disease.
"All mice" ...All mice exhibited histopathologic changes in lungs two days after challenge including all animals vaccinated
Caution in proceeding to application of a SARS-CoV vaccine in humans is indicated.