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(The Washington Post) There’s no one ‘gay gene,’ but genetics are linked to same-sex behavior, new study says. Associated research findings from the National Library of Medicine.
www.ncbi.nlm.nih.gov
genetics are linked to same-sex behavior, new study says
by Lindsey Bever
DNA from hundreds of thousands of people revealed a handful of genetic variants connected with same-sex sexual behavior.
Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 individuals, revealing five loci significantly associated...
pubmed.ncbi.nlm.nih.gov
Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior
Twin and family studies have shown that same-sex sexual behavior is partly genetically influenced, but previous searches for specific genes involved have been underpowered. We performed a genome-wide association study (GWAS) on 477,522 individuals, revealing five loci significantly associated with same-sex sexual behavior. In aggregate, all tested genetic variants accounted for 8 to 25% of variation in same-sex sexual behavior, only partially overlapped between males and females, and do not allow meaningful prediction of an individual's sexual behavior. Comparing these GWAS results with those for the proportion of same-sex to total number of sexual partners among nonheterosexuals suggests that there is no single continuum from opposite-sex to same-sex sexual behavior. Overall, our findings provide insights into the genetics underlying same-sex sexual behavior and underscore the complexity of sexuality.
Ganna A, Verweij KJH, Nivard MG, Maier R, Wedow R, Busch AS, Abdellaoui A, Guo S, Sathirapongsasuti JF; 23andMe Research Team; Lichtenstein P, Lundström S, Långström N, Auton A, Harris KM, Beecham GW, Martin ER, Sanders AR, Perry JRB, Neale BM, Zietsch BP. Large-scale GWAS reveals insights into the genetic architecture of same-sex sexual behavior. Science. 2019 Aug 30;365(6456):eaat7693. doi: 10.1126/science.aat7693. PMID: 31467194; PMCID: PMC7082777.
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